Seamer Lutho Sipamla made his debut in South Africa on Friday at the opening match of the T20 against Pakistan in Cape Town.
20-year-old Sipamla was named to the squad after being impressed with Eastern Province and Spartans in the Manzai Super League.
The Proteas, which ranked fifth in the T20 world rankings, could also include Beuran Hendricks after the Seamer added two ODI caps to its last seven T20 appearances in the final series.
Pakistan, whose strength in this format has brought them to the top of the world rankings, is again led by Shoaib Malik in the absence of Sarfraz Ahmed.
Sarfraz led Pakistan to eleven consecutive T20 series victories, but remains banned for its racist comments on Andile Phehlukwayo.
The selectors will probably have to choose between Hussain Talat and Imad Wasim, while Mohammad Rizwan will take the gloves.
The teams contest three games in the series. Other games take place on Sunday and Wednesday in Johannesburg and Centurion.